Division of Biochemistry

Biology meets chemistry; this division elucidates the mechanisms behind intra/inter-cellular recognition, stimuli response, and biomolecular synthesis in living organisms, leading to the development of pioneering novel materials.

Prof FUTAKI, Shiroh (D Pharm Sc)

The ultimate goal of our research is the regulation of cellular functions by designed peptides and proteins. Current projects include “Development of membrane permeable peptide vectors”, “Design of peptides inducing structural changes of the plasma membrane”, and “Creation of nucleic acids-binding proteins with desired sequence specificities and control of cellular functions”.

Assist prof WATANABE, Bunta (D Agr)

Life consists of integrated chemical reactions mediated by enzymes. The aim of our research is to design and synthesis of novel and specific inhibitors of enzymes and transporters for use as chemical tools to understand and control the physiological functions of the proteins and for lead generation of novel medicinal and agrochemical agents, and cosmetic ingredients.

div3_hiratake

Glutathione (GSH) metabolism and enzyme inhibitors

Prof AOYAMA, Takashi (D Sc)

We are interested in the signal transduction and gene expression for the regulation of plant morphogenesis. Targets of our study include the involvement of phospholipid signaling in cell morphogenesis, the cytokinin signal transduction mediated by the transcription factor ARR1, and the regulatory mechanism of plant morphogenesis by the COP9 signalosome.

The Arabidopsis phospholipid signaling
factor PIP5K3 specifically localizing at
the tips of elongating root hairs.

Prof UESUGI, Motonari (D Pharm Sc)

Small organic molecules have been utilized to improve human health and to elucidate the secrets of life. Discovery or design of small organic molecules with unique biological activity permits small-molecule-initiated exploration of cells and living organisms. Our laboratory has been discovering small organic molecules that modulate a range of biological events and use them as tools to explore and control biological events.