Professor UESUGI, Motonari and his research group from iCeMS “A small molecule that blocks fat synthesis” Published in “Chemistry&Biology”, 28 Oct. 2009

Professor UESUGI, Motonari and his reserch group

Institute for Chemical Research and Institute for Integrated Cell-Material Sciences(iCeMS)

 

“A small molecule
that blocks fat synthesis”

Published in “Chemistry&Biology”, 28 August 2009

Professor UESUGI, Motonari

Biosynthesis of cholesterols and fatty acids from carbohydrates requires a large number of enzymes. Transcription of many of the genes encoding these enzymes is regulated by transcription factors called sterol regulatory element binding proteins (SREBPs).

Fatostatin

  In the present study, our research group showed that a small synthetic molecule we previously discovered to block adipogenesis is an inhibitor of the SREBP activation. The diarylthiazole derivative, now called fatostatin, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells.

 In the present study, our research group showed that a small synthetic molecule we previously discovered to block adipogenesis is an inhibitor of the SREBP activation. The diarylthiazole derivative, now called fatostatin, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells.